http://v3.espacenet.com/origdoc?DB=EPODOC&IDX=JP6107565&F=0&QPN=JP6107565
PHYSICAL ADSORPTION-TYPE POLYMER MICELLE MEDICINE
Bibliographic data Description Claims Mosaics Original document INPADOC legal status
Publication number: JP6107565
Publication date: 1994-04-19
Inventor: YOKOYAMA MASAYUKI; SAKURAI YASUHISA; OKANO MITSUO; KATAOKA KAZUNORI
Applicant: JAPAN RES DEV CORP
Classification:
- international: A61K9/00; A61K9/107; A61K9/51; A61K47/34; A61K47/48; C08G69/10; A61K9/00; A61K9/107; A61K9/51; A61K47/34; A61K47/48; C08G69/00; (IPC1-7): A61K47/34; A61K9/00; A61K9/107
- European: A61K9/107D; A61K9/51; A61K47/48W6B; C08G69/10
Application number: JP19930192586 19930803
Priority number(s): JP19930192586 19930803; JP19920217044 19920814
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Also published as:
EP0583955 (A2)
US5449513 (A1)
EP0583955 (A3)
EP0583955 (B1)
AU668967B (B2)
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Abstract of JP6107565
PURPOSE:To provide a drug-supporting carrier composed of a block copolymer having hydrophilic segment and hydrophobic segment and capable of physically bonding a hydrophobic drug. CONSTITUTION:A block copolymer is produced by polymerizing a hydrophilic segment (e.g. polyethylene oxide) and a hydrophobic segment [e.g. poly(beta-benzyl- L-aspartate)]. A hydrophobic drug is supported on a drug-supporting carrier consisting of the block copolymer by physical means such as heat-treatment, ultrasonic irradiation and organic solvent treatment. The drug is supported in a polymer micelle by this process to obtain a polymeric micelle drug allowing various combinations of hydrophobic drug and block copolymer. Since the included drug is stably supported in the micelle even in the presence of serum and has high hydrophobicity, a drug having poor water-solubility and difficult to be administered to living body can be administered in the form of a polymeric micelle.
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